Challenge IM Filtration Systems
Effortless Automation for Extended Filtration
Runs from R&D to GMP‑ready production
How do you automate long filtration runs without sacrificing control or scalability?
The Challenge IM filtration systems offer two GMP-Ready options for gentle and scalable bioprocessing.
Challenge IM Dream Tangential Flow Filtration (TFF) System
Take a look at some of the features
Intelligent automation that simplifies operation and boosts efficiency
Platform delivers intelligent automation for bioprocessing and laboratory operations. Reduces manual workload.
GMP compliant device
Built to meet Good Manufacturing Practice requirements. Suitable for highly regulated environments.
Supports a reliable and stable development environment
A robust hardware and software architecture supports a stable and reproducible development environment.
Large range of specifications to suit requirements
A wide range of configurable specifications allows the system to be tailored to evolving process needs.
One platform for R&D, scale‑up, and commercial production
A single, integrated platform supports R&D, scale‑up, and commercial production, reducing complexity and eliminating the need for multiple systems.
User friendly navigator software
Intuitive user‑friendly software enables fast onboarding and efficient operation.
Offers fully digitised, 21 CFR Part 11‑compliant data management
The platform offers fully digitised data management ensuring secure, traceable, and auditable records.
Wide range of applications
Designed for versatility, the system supports a wide range of applications across research, development, and manufacturing.
Normal Flow Filtration (NFF) System
Gentle Processing for Maximum Cell Viability
Low-shear pump control and real-time TMP monitoring protect sensitive cells and biomolecules, ensuring high biological activity and product integrity.
Fully Automated & GMP-Compliant
Hands-free operation with 21 CFR Part 11–compliant software delivers consistent performance, robust data integrity, and simplified regulatory compliance.
End-to-End Filtration Performance
Supports critical applications from clarification and bioburden reduction to final sterile filtration—ensuring reliability across upstream and downstream processes.
Universal System Compatibility
Open hardware design integrates seamlessly with cassettes and hollow fibres from all major suppliers, protecting existing workflows and investments.
Scalable & Process-Flexible Platform
Engineered to bridge development and GMP manufacturing, enabling smooth scale-up without added complexity.
Improved Throughput & Lower Costs
Optimised flow control and reduced fouling extend filter life, increase process efficiency, and lower overall cost of goods while maintaining product quality.
From Challenge IM, the Challenge Dream Tangential Flow Filtration TFF system is a fully automated, GMP-ready platform designed to support upstream and downstream workflows.
The system is suitable for early process development through to pilot scale and commercial production.
Combining intelligent software, modular hardware, and single‑use flexibility, it delivers stable, repeatable performance while enabling seamless scale‑up and long, unattended filtration runs.
Integrated Normal Flow Filtration (NFF) capabilities enable efficient clarification, bioburden reduction, and final sterile filtration, protecting downstream processes and ensuring consistent product quality.
With precise control of flow and pressure, the system reduces fouling, extends filter life, and improves throughput while maintaining full GMP compliance.
Applications of the Challenge IM Dream TFF Auto System
– Collection and concentration of bacterial cells
– Clarification of cell culture supernatants and cell lysates
– Protein concentration, purification, and buffer exchange
– Separation, purification, and concentration of polysaccharides
– Plasmid purification and concentration
– Concentration of viruses, virus-like particles, and viral vectors
– Diafiltration and concentration of liposomes, latex, and nanoparticles
– Endotoxin removal from biological samples, raw materials, and traditional medicines
– Endotoxin removal from buffers and cell culture media
– Alcohol removal, concentration, and metal ion removal from blood products
Speak to a filtration specialist
info@a-i-bioprocessing-limited.odoo.com
Phone
+447783341220
Office
Newport Pagnell, England
